Biophysics, Pathophysiology and Pharmacology of Ion Channel Gating Pores

Biophysics, Pathophysiology and Pharmacology of Ion Channel Gating Pores

Voltage sensor domain (VSDs) are a feature of voltage gated ion channel (VGICs) and voltage sensitive proteins. They are composed of four transmembrane (TM) segments (S1 to S4). Currents leaking through VSDs are called omega or gating pore currents.<br/>Gating pores are caused by mutations of...

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Bibliographic Details
Main Authors: Adrien eMoreau, Pascal eGosselin-Badaroudine, Mohamed eChahine
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Channelopathies
Ion Channels
Sodium Channels
voltage sensor domain
Gating charge transfer center
Omega pores.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00053/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00053/full

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