RTA and LANA Competitively Regulate let-7a/RBPJ Signal to Control KSHV Replication

RTA and LANA Competitively Regulate let-7a/RBPJ Signal to Control KSHV Replication

The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) has a dual effect on Kaposi’s sarcoma-associated herpesvirus (KSHV) replication. RBPJ interaction with replication and transcription activator (RTA) is essential for lytic replication, while the interaction with latenc...

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Bibliographic Details
Main Authors: Chunhong Di, Guoxia Zheng, Yunheng Zhang, Enyu Tong, Yanli Ren, Yu Hong, Yang Song, Rong Chen, Xiaohua Tan, Lei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Microbiology
Subjects:
Kaposi’s sarcoma-associated herpesvirus
replication and transcription activator
latency-associated nuclear antigen
let-7a
RBPJ
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.804215/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.804215/full

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