Photoswitchable Azo- and Diazocine-Functionalized Derivatives of the VEGFR-2 Inhibitor Axitinib

Photoswitchable Azo- and Diazocine-Functionalized Derivatives of the VEGFR-2 Inhibitor Axitinib

In this study, we aimed at the application of the concept of photopharmacology to the approved vascular endothelial growth factor receptor (VEGFR)-2 kinase inhibitor axitinib. In a previous study, we found out that the photoisomerization of axitinib’s stilbene-like double bond is unidirectional in a...

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Bibliographic Details
Main Authors: Linda Heintze, Dorian Schmidt, Theo Rodat, Lydia Witt, Julia Ewert, Malte Kriegs, Rainer Herges, Christian Peifer
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
photopharmacology
diazocine
azobenzene
photoswitchable kinase inhibitor
axitinib
VEGFR
Online Access:https://www.mdpi.com/1422-0067/21/23/8961

Internet

https://www.mdpi.com/1422-0067/21/23/8961

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