A Computational Model of the Trans-Synaptic Spread of Pathogenic Tau in Early Alzheimer’s Disease

A Computational Model of the Trans-Synaptic Spread of Pathogenic Tau in Early Alzheimer’s Disease

Alzheimer’s Disease is an extremely prevalent neurodegenerative disorder which causes progressive cognitive decline. This disease is associated with the spread of pathogenic tau protein, which starts in the transentorhinal cortex and progresses to other limbic and cortical areas. Tau is an important...

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Bibliographic Details
Main Authors: Bashir Sbaiti, Michael Khalfin, Marianne Bezair
Format: Article
Language:English
Published: Appalachian State University Honors College 2021-12-01
Series:Impulse: The Premier Undergraduate Neuroscience Journal
Subjects:
neurodegenerative disease
tau propagation
small-world network
therapeutic intervention
tau reduction
tauopathy
Online Access:https://impulse.appstate.edu/articles/2021/computational-model-trans-synaptic-spread-pathogenic-tau-early-alzheimer%E2%80%99s-disease

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https://impulse.appstate.edu/articles/2021/computational-model-trans-synaptic-spread-pathogenic-tau-early-alzheimer%E2%80%99s-disease

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