Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer

Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer

Cofilin-1 (CFL1) overexpression in pancreatic cancer correlates with high invasiveness and shorter survival. Besides a well-documented role in actin remodeling, additional cellular functions of CFL1 remain poorly understood. Here, we unraveled molecular tumor-promoting functions of CFL1 in pancreati...

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Bibliographic Details
Main Authors: Silke D. Werle, Julian D. Schwab, Marina Tatura, Sandra Kirchhoff, Robin Szekely, Ramona Diels, Nensi Ikonomi, Bence Sipos, Jan Sperveslage, Thomas M. Gress, Malte Buchholz, Hans A. Kestler
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
pancreatic cancer
cofilin-1
modeling
molecular mechanism
Boolean networks
predicting therapeutic targets
Online Access:https://www.mdpi.com/2072-6694/13/4/725

Internet

https://www.mdpi.com/2072-6694/13/4/725

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