Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine

Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine

Background/Aims: Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge. Methods: We detected the expression levels of the bone morphogenetic protein (BMP) i...

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Bibliographic Details
Main Authors: Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai, Tuo Jin, Xiaodong Chen, Xiaoling Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Human bone marrow mesenchymal stem cells
Chordin
Bone morphogenetic protein-2
Polyspermine imidazole-4
5-imine
Osteogenesis
Online Access:https://www.karger.com/Article/FullText/488416

Internet

https://www.karger.com/Article/FullText/488416

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