Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles

Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles

A new route to bicyclic γ-lactams was found, which was proposed as a three-component cyclization of ethyl trifluoropyruvate with methyl ketones and 1,2-, 1,3-amino alcohols. As a result, a series of trifluoromethyl-substituted tetrahydropyrrolo [2,1-<i>b</i>]oxazol-5-ones and tetrahydrop...

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Bibliographic Details
Main Authors: Marina V. Goryaeva, Olesya A. Fefelova, Yanina V. Burgart, Marina A. Ezhikova, Mikhail I. Kodess, Pavel A. Slepukhin, Vasily S. Gaviko, Victor I. Saloutin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
multicomponent domino cyclizations
ethyl trifluoropyruvate
methyl ketones
amino alcohols
γ-lactams
tetrahydropyrrolo[2,1-<i>b</i>]oxazolones
Online Access:https://www.mdpi.com/1420-3049/28/4/1983

Internet

https://www.mdpi.com/1420-3049/28/4/1983

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