Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases

Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases

Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell types in the lamina propria (LP), including af...

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Bibliographic Details
Main Authors: Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
urothelium
bladder
nucleotidases
purine nucleotides
ATP-adenosine triphosphate
ADP
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.918100/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.918100/full

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