Accumulation of Nucleolar Inorganic Polyphosphate Is a Cellular Response to Cisplatin-Induced Apoptosis

Accumulation of Nucleolar Inorganic Polyphosphate Is a Cellular Response to Cisplatin-Induced Apoptosis

The chemotherapeutic drug cisplatin, which targets DNA, serves as one of the main staples in cancer treatment. Yet, the therapeutic application of cisplatin is limited by two major challenges: the occurrence of reversible and irreversible side effects due to non-specific toxicity, and the intrinsic...

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Bibliographic Details
Main Authors: Lihan Xie, Asavari Rajpurkar, Ellen Quarles, Nicole Taube, Akash S. Rai, Jake Erba, Benjamin Sliwinski, Moses Markowitz, Ursula Jakob, Daniela Knoefler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
cisplatin
polyphosphate
apoptosis
caspases
nucleolus
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01410/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01410/full

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