Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility

Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility

Vaccination with intact (146S) foot-and-mouth disease virus (FMDV) particles is used to control FMD. However, 146S particles easily dissociate into stable pentameric 12S particles which are less immunogenic. We earlier isolated several single-domain antibody fragments (VHHs) that specifically bind e...

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Bibliographic Details
Main Authors: Michiel M. Harmsen, Haozhou Li, Shiqi Sun, Wim H. M. van der Poel, Aldo Dekker
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Veterinary Science
Subjects:
neutralizing antibody
epitope
XL-MS
nanobody
VHH
ELISA
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.1040802/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2022.1040802/full

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