Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss

Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss

The reactive oxygen species (ROS)-generating enzyme NOX3 has recently been implicated in the pathophysiology of several acquired forms of sensorineural hearing loss, including cisplatin-, noise- and age-related hearing loss. NOX3 is highly and specifically expressed in the inner ear and therefore re...

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Bibliographic Details
Main Authors: German Nacher-Soler, Antoine Marteyn, Natasha Barenzung, Stéphanie Sgroi, Karl-Heinz Krause, Pascal Senn, Francis Rousset
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neurology
Subjects:
gene silencing
NADPH oxidase 3
NOX3
inner ear delivery
inner ear therapy
canalostomy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.993017/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.993017/full

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