Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.

Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.

Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV combinati...

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Bibliographic Details
Main Authors: Rajesh Panigrahi, Sidhartha Hazari, Sruti Chandra, Partha K Chandra, Sibnarayan Datta, Ramazan Kurt, Craig E Cameron, Zhuhui Huang, Haitao Zhang, Robert F Garry, Luis A Balart, Srikanta Dash
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3751885?pdf=render

Internet

http://europepmc.org/articles/PMC3751885?pdf=render

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