Understanding Osaka mutation polymorphic Aβ fibril response to static and oscillating electric fields: insights from computational modeling

Understanding Osaka mutation polymorphic Aβ fibril response to static and oscillating electric fields: insights from computational modeling

Abstract Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, impacting millions of individuals worldwide. Among its defining characteristics is the accumulation of senile plaques within the brain’s gray matter, formed through the self-assembly of misfolded proteins contributing to th...

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Bibliographic Details
Main Authors: Mukhriddin Makhkamov, Artyom Baev, Erkin Kurganov, Jamoliddin Razzokov
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Polymorphic Aβ fibril
Osaka mutation
Molecular dynamics
Electric field
Unfolding
Online Access:https://doi.org/10.1038/s41598-024-72778-1

Internet

https://doi.org/10.1038/s41598-024-72778-1

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