Low-coverage whole-genome sequencing of cerebrospinal-fluid-derived cell-free DNA in brain tumor patients

Low-coverage whole-genome sequencing of cerebrospinal-fluid-derived cell-free DNA in brain tumor patients

Summary: This protocol summarizes the pipeline for analysis of tumor-derived cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) using low-coverage whole-genome sequencing (lcWGS). This approach enables resolution of chromosomal and focal copy-number variations (CNVs) as oncologic signatures, parti...

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Bibliographic Details
Main Authors: Anthony P.Y. Liu, Kyle S. Smith, Rahul Kumar, Giles W. Robinson, Paul A. Northcott
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:STAR Protocols
Subjects:
Bioinformatics
Sequence analysis
Cancer
Health Sciences
Clinical Protocol
Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722001721

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http://www.sciencedirect.com/science/article/pii/S2666166722001721

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