AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis

AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis

Oriented cell divisions balance self-renewal and differentiation in stratified epithelia such as the skin epidermis. During peak epidermal stratification, the distribution of division angles among basal keratinocyte progenitors is bimodal, with planar and perpendicular divisions driving symmetric an...

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Bibliographic Details
Main Authors: Carlos P Descovich, Kendall J Lough, Akankshya Jena, Jessica J Wu, Jina Yom, Danielle C Spitzer, Manuela Uppalapati, Katarzyna M Kedziora, Scott E Williams
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
oriented cell divisions
spindle orientation
epithelial cells
epidermis
Online Access:https://elifesciences.org/articles/80403

Internet

https://elifesciences.org/articles/80403

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