Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis.

Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis.

Blockade of Prostaglandin (PG) E(2) production via deletion of microsomal Prostaglandin E synthase-1 (mPGES-1) gene reduces tumor cell proliferation in vitro and in vivo on xenograft tumors. So far the therapeutic potential of the pharmacological inhibition of mPGES-1 has not been elucidated. PGE(2)...

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Bibliographic Details
Main Authors: Federica Finetti, Erika Terzuoli, Elena Bocci, Isabella Coletta, Lorenzo Polenzani, Giorgina Mangano, Maria Alessandra Alisi, Nicola Cazzolla, Antonio Giachetti, Marina Ziche, Sandra Donnini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3399882?pdf=render

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http://europepmc.org/articles/PMC3399882?pdf=render

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