Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo

Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo

Colistin is used as the “last line of defense” against multidrug-resistant (MDR) Gram-negative bacteria (GNB). However, improper use of colistin may further lead to an increasing number of colistin-resistant (Col-R) strains worldwide, which greatly limits antibiotic treatment options. In this study,...

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Bibliographic Details
Main Authors: Mengxin Xu, Zhuocheng Yao, Yining Zhao, Shiyi Shi, Yao Sun, Luozhu Feng, Cui Zhou, Xiaodong Zhang, Jianming Cao, Tieli Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Microbiology
Subjects:
colistin resistance
synergistic effect
naringenin
biofilm
gram-negative bacteria
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.916587/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.916587/full

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