Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

Highlights ICOS agonist antibody (ICOSaa) promotes paclitaxel-evoked pain resolution in female mice. DRG T cells appear to enter an anti-inflammatory phenotype by ICOSaa treatment. ICOSaa treatment increases DRG levels of IL-10 cytokine. ICOSaa effects in female mice are blocked by IL-10 sequesterin...

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Bibliographic Details
Main Authors: Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Juliet M. Mwirigi, Galo L. Mejia, Michael D. Burton, Theodore J. Price
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
Inducible co-stimulatory molecule
CIPN
T cells
Pain
IL-10 cytokine
Online Access:https://doi.org/10.1186/s12974-023-02719-8

Internet

https://doi.org/10.1186/s12974-023-02719-8

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