One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from <i>Streptomyces cacaoi</i> CA-170360

One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from <i>Streptomyces cacaoi</i> CA-170360

The strain <i>Streptomyces cacaoi</i> CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gene cluster. In this work, we have cl...

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Bibliographic Details
Main Authors: Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Daniel Carretero-Molina, Fernando Reyes, Olga Genilloud
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Microorganisms
Subjects:
pentaminomycin
BE-18257
heterologous expression
Cas9-assisted targeting of chromosome segments (CATCH) cloning
non-ribosomal peptide synthetases (NRPS)
secondary metabolites
Online Access:https://www.mdpi.com/2076-2607/9/1/135

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https://www.mdpi.com/2076-2607/9/1/135

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