The study of FGFR3 ⁃ TACC3 fusion gene mediating pyruvate kinase M2 nuclear translocation to promote DNA damage repair in glioblastoma

The study of FGFR3 ⁃ TACC3 fusion gene mediating pyruvate kinase M2 nuclear translocation to promote DNA damage repair in glioblastoma

Objective To explore the mechanism of FGFR3⁃TACC3 (F3⁃T3) fusion gene mediating DNA damage repair through promoting pyruvate kinase M2 (PKM2)'s nuclear translocation in glioblastoma. Methods The lentiviral transfection technology was used to constructed stable transitional cell lines U87MG cell...

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Bibliographic Details
Main Authors: REN Xiu⁃de, LI Tao, FAN Ji⁃kang, WANG Xi⁃sen, JIA Xiao⁃dan, YANG Xue⁃jun
Format: Article
Language:English
Published: Tianjin Huanhu Hospital 2023-08-01
Series:Chinese Journal of Contemporary Neurology and Neurosurgery
Subjects:
glioblastoma
receptor, fibroblast growth factor, type 3
gene fusion
pyruvate kinase
dna repair
temozolomide
drug resistance, neoplasm
cell proliferation
immunoblotting
tumor cells, cultured
disease models, animal
Online Access:http://www.cjcnn.org/index.php/cjcnn/article/view/2743

Internet

http://www.cjcnn.org/index.php/cjcnn/article/view/2743

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