Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 (IL12) and type I Interferons (IFN) which contribute to autoimmune disorders (e.g., psoriasis, lupus, and inflammatory bowel...

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Bibliographic Details
Main Authors: Yu Zhou, Xin Li, Ru Shen, Xiangzhu Wang, Fan Zhang, Suxing Liu, Di Li, Jian Liu, Puhui Li, Yinfa Yan, Ping Dong, Zhigao Zhang, Heping Wu, Linghang Zhuang, Rasheduzzaman Chowdhury, Matthew Miller, Mena Issa, Yuchang Mao, Hongli Chen, Jun Feng, Jing Li, Chang Bai, Feng He, Weikang Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Tyrosine Kinase 2 (TYK2)
Janus Kinases (JAK)
JAK homology 2 (JH2) pseudokinase regulatory domain
cytokine pathways
small molecule inhibitors
selectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884399/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.884399/full

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