Engaging an HIV vaccine target through the acquisition of low B cell affinity

Engaging an HIV vaccine target through the acquisition of low B cell affinity

Abstract Low affinity is common for germline B cell receptors (BCR) seeding development of broadly neutralizing antibodies (bnAbs) that engage hypervariable viruses, including HIV. Antibody affinity selection is also non-homogenizing, insuring the survival of low affinity B cell clones. To explore w...

Full description

Bibliographic Details
Main Authors: Larance Ronsard, Ashraf S. Yousif, Faez Amokrane Nait Mohamed, Jared Feldman, Vintus Okonkwo, Caitlin McCarthy, Julia Schnabel, Timothy Caradonna, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, Aaron Schmidt, Daniel Lingwood
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40918-2

Internet

https://doi.org/10.1038/s41467-023-40918-2

Similar Items