Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides L-M and Pharmacological Characterization of Taveuniamide F as a GPCR Antagonist with CNR1 Selectivity

Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides L-M and Pharmacological Characterization of Taveuniamide F as a GPCR Antagonist with CNR1 Selectivity

NMR and MS/MS-based metabolomics of a cyanobacterial extract from Piti Bomb Holes, Guam, indicated the presence of unique enyne-containing halogenated fatty acid amides. We isolated three new compounds of this class, taveuniamides L-N (<b>1</b>–<b>3</b>)<b>,</b> a...

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Bibliographic Details
Main Authors: Lobna A. Elsadek, Emma K. Ellis, Gustavo Seabra, Valerie J. Paul, Hendrik Luesch
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Marine Drugs
Subjects:
fatty acid amides
chlorinated enyne
GPCR
CNR1
cyanobacteria
Online Access:https://www.mdpi.com/1660-3397/22/1/28

Internet

https://www.mdpi.com/1660-3397/22/1/28

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