Parkin coregulates glutathione metabolism in adult mammalian brain

Parkin coregulates glutathione metabolism in adult mammalian brain

Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adu...

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Main Authors: Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
格式: 文件
语言:English
出版: BMC 2023-01-01
丛编:Acta Neuropathologica Communications
主题:
Early-onset Parkinson disease
Parkin
Prkn
Sod2
Redox stress
Glutathione metabolism
在线阅读:https://doi.org/10.1186/s40478-022-01488-4

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https://doi.org/10.1186/s40478-022-01488-4

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