Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer

Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer

Abstract Background Leptomeningeal metastases (LM) were rare in gastric cancer (GC), and GC patients with LM (GCLM) generally suffer from poor prognosis. Nevertheless, the clinical utility of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) was underinvestigated in GCLM. Methods We retrospect...

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Bibliographic Details
Main Authors: Xin Chen, Kaixuan Bai, Yu Zhang, Yang Xu, Yinghao Huo, Sha Wang, Yueli Zou, Xuejiao Qi, Rongyun Guo, Qiuxiang Ou, Dengxiang Liu, Shaohua Yin, Shubo Chen, Hui Bu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Leptomeningeal metastases
Gastric cancer
Cerebrospinal fluid
ctDNA
Prognosis
Online Access:https://doi.org/10.1186/s12967-023-04077-8

Internet

https://doi.org/10.1186/s12967-023-04077-8

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