IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin

IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin

Abstract Introduction There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring the underlying mechanisms and developing safe and effective medicines to alleviate MT-induced he...

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Bibliographic Details
Main Authors: Rui Shi, Zhenhua Liu, Huan Yue, Man Li, Simin Liu, Dema De, Runjing Li, Yunan Chen, Shuli Cheng, Xiaoming Gu, Min Jia, Jun Li, Juan Li, Shumiao Zhang, Na Feng, Rong Fan, Feng Fu, Yali Liu, Mingge Ding, Jianming Pei
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
Mechanical trauma
Melatonin
MAMs
ERK1/2
FoxO1
IP3R1
Online Access:https://doi.org/10.1186/s11658-023-00509-x

Internet

https://doi.org/10.1186/s11658-023-00509-x

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