Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts (OCLs). However, the molecular mechanisms und...

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Bibliographic Details
Main Authors: Kumaran Sundaram, Yuvaraj Sambandam, Srinivasan Shanmugarajan, D. Sudhaker Rao, Sakamuri V. Reddy
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Bone Reports
Subjects:
Paget's disease of bone
Osteoclast
MVNP
DAP12
SIRPβ1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187216300249

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http://www.sciencedirect.com/science/article/pii/S2352187216300249

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