Pre-Clinical Assessment of Roflumilast Therapy in a Thoracic Model of Spinal Cord Injury

Pre-Clinical Assessment of Roflumilast Therapy in a Thoracic Model of Spinal Cord Injury

The failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury cascade, creating a hostile microenvironment, which not only is not permissive to regeneration but also leads to...

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Bibliographic Details
Main Authors: Carla S. Sousa, Rui Lima, Jorge R. Cibrão, Eduardo D. Gomes, Luís S. Fernandes, Tiffany S. Pinho, Deolinda Silva, Jonas Campos, António J. Salgado, Nuno A. Silva
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
Roflumilast
spinal cord injury
motor recovery
rat model
Online Access:https://www.mdpi.com/1999-4923/15/5/1556

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https://www.mdpi.com/1999-4923/15/5/1556

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