Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1

Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1

Abstract X-linked lymphoproliferative disease (XLP) is either caused by loss of the SLAM-associated protein (SAP; XLP-1) or the X-linked inhibitor of apoptosis (XIAP; XLP-2). In both instances, infection with the oncogenic human Epstein Barr virus (EBV) leads to pathology, but EBV-associated lymphom...

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Bibliographic Details
Main Authors: Christine Engelmann, Patrick Schuhmachers, Hana Zdimerova, Sanamjeet Virdi, Mathias Hauri-Hohl, Jana Pachlopnik Schmid, Adam Grundhoff, Rebecca A. Marsh, Wendy Wei-Lynn Wong, Christian Münz
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05337-z

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https://doi.org/10.1038/s41419-022-05337-z

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