Curcumin Acts as a Chemosensitizer for Leiomyosarcoma Cells In Vitro But Fails to Mediate Antioxidant Enzyme Activity in Cisplatin-Induced Experimental Nephrotoxicity in Rats

Curcumin Acts as a Chemosensitizer for Leiomyosarcoma Cells In Vitro But Fails to Mediate Antioxidant Enzyme Activity in Cisplatin-Induced Experimental Nephrotoxicity in Rats

Background. Cisplatin (cis-diamminedichloroplatinum) is a widely used chemotherapeutic agent for the treatment of various cancers. Although it represents an effective regimen, its application is accompanied by side effects to normal tissues, especially to the kidneys. Cisplatin generates free radica...

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Main Authors: Irida Dhima MSc, PhD, Stelios Zerikiotis MSc, PhD, Panagiotis Lekkas MSc, PhD, Yannis V. Simos MSc (MedSci), PhD, Maria Gkiouli MSc, PhD, Patra Vezyraki MD, PhD, Evangelia Dounousi MD, PhD, Vasilios Ragos MD, PhD, Xenophon Giannakopoulos MD, PhD, Dimitrios Baltogiannis MD, PhD, Vasiliki Kalfakakou MD, PhD, Angelos Evangelou MD, PhD, Dimitrios Peschos MD, PhD, Spyridon Karkabounas PhD
Format: Article
Language:English
Published: SAGE Publishing 2019-08-01
Series:Integrative Cancer Therapies
Online Access:https://doi.org/10.1177/1534735419872811

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https://doi.org/10.1177/1534735419872811

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