Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes

Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes

Abstract Background As one possible solution to the “missing heritability” problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology. However, while a number of methods for pathway-based rare-variant ana...

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Bibliographic Details
Main Authors: Sungyoung Lee, Yongkang Kim, Sungkyoung Choi, Heungsun Hwang, Taesung Park
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Bioinformatics
Subjects:
Pathway-based analysis
Next-generation sequencing data
Multivariate analysis
Generalized structured component analysis
Hierarchical analysis
Online Access:http://link.springer.com/article/10.1186/s12859-018-2066-9

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http://link.springer.com/article/10.1186/s12859-018-2066-9

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