Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects

Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the immunomodulatory effects of such treatment. Clinical...

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Bibliographic Details
Main Authors: Dihia Meghnem, Sharon A. Oldford, Ian D. Haidl, Lisa Barrett, Jean S. Marshall
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88829-w