MFG-E8 Reduces Aortic Intimal Proliferation in a Murine Model of Transplant Vasculopathy

MFG-E8 Reduces Aortic Intimal Proliferation in a Murine Model of Transplant Vasculopathy

Transplant vasculopathy is characterized by endothelial apoptosis, which modulates the local microenvironment. Milk fat globule epidermal growth factor 8 (MFG-E8), which is released by apoptotic endothelial cells, limits tissue damage and inflammation by promoting anti-inflammatory macrophages. We a...

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Bibliographic Details
Main Authors: Benoit Brilland, Patrick Laplante, Pamela Thebault, Karen Geoffroy, Marie-Joëlle Brissette, Mathieu Latour, Michaël Chassé, Shijie Qi, Marie-Josée Hébert, Héloïse Cardinal, Jean-François Cailhier
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
MFG-E8
macrophage reprogramming
T-cell activation
aortic transplantation
transplant vasculopathy
murine model
Online Access:https://www.mdpi.com/1422-0067/23/8/4094

Internet

https://www.mdpi.com/1422-0067/23/8/4094

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