HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways

HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways

Measure of drug-mediated immune reactions that are dependent on the patient’s genotype determine individual medication protocols. Despite extensive clinical trials prior to the license of a specific drug, certain patient-specific immune reactions cannot be reliably predicted. The need for acknowledg...

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Bibliographic Details
Main Authors: Funmilola Josephine Haukamp, Zoe Maria Hartmann, Andreas Pich, Joachim Kuhn, Rainer Blasczyk, Florian Stieglitz, Christina Bade-Döding
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
adverse drug reaction
HLA
carbamazepine hypersensitivity
carbamazepine
carbamazepine-10,11-epoxide
proteome
Online Access:https://www.mdpi.com/2073-4409/12/5/676

Internet

https://www.mdpi.com/2073-4409/12/5/676

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