Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Abstract Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the NFATC1 transcription factor and its...

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Bibliographic Details
Main Authors: Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
Prostate cancer
Metastatic carcinoma
NFATC1
PIM kinases
Cell motility
Online Access:http://link.springer.com/article/10.1186/s12964-019-0463-y

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http://link.springer.com/article/10.1186/s12964-019-0463-y

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