The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Introduction: Growing evidence has shown the correlation between periodontitis and atherosclerosis, while our knowledge on the pathogenesis of periodontitis-promoting atherosclerosis is far from sufficient. Objectives: Illuminate the pathogenic effects of Fusobacterium nucleatum (F. nucleatum) on in...

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Bibliographic Details
Main Authors: Song Shen, Tianyong Sun, Xiangjiu Ding, Xiufeng Gu, Yushang Wang, Xiaomei Ma, Zixuan Li, Haiting Gao, Shaohua Ge, Qiang Feng
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Advanced Research
Subjects:
Fusobacterium nucleatum
Lipid deposition
Gbp
CypA
RNA-seq
Drug repositioning
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223001133

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http://www.sciencedirect.com/science/article/pii/S2090123223001133

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