Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)

Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)

Abstract Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for...

Full description

Bibliographic Details
Main Authors: Urvashi Sharma, Sandrine Vadon-Le Goff, Karl Harlos, Yuguang Zhao, Natacha Mariano, Cecile Bijakowski, Jean-Marie Bourhis, Catherine Moali, David J. S. Hulmes, Nushin Aghajari
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18795-4

Internet

https://doi.org/10.1038/s41598-022-18795-4

Similar Items