Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors.

Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors.

Although tumors naturally prime adaptive immune responses, tolerance may limit the capacity to control progression and can compromise effectiveness of immune-based therapies for cancer. Post-proline cleaving enzymes (PPCE) modulate protein function through N-terminal dipeptide cleavage and inhibitio...

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Bibliographic Details
Main Authors: Meghaan P Walsh, Brynn Duncan, Shannon Larabee, Aviva Krauss, Jessica P E Davis, Yongzhi Cui, Su Young Kim, Martin Guimond, William Bachovchin, Terry J Fry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3595211?pdf=render

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http://europepmc.org/articles/PMC3595211?pdf=render

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