Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case–control study

Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case–control study

Abstract Background Pathogenic variants (PVs) of BRCA genes entail a lifetime risk of developing breast cancer in 50–85% of carriers. Their prevalence in different populations has been previously reported. However, there is scarce information regarding the most common PVs of these genes in Latin-Ame...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Omar Alejandro Zayas-Villanueva, Luis Daniel Campos-Acevedo, José de Jesús Lugo-Trampe, David Hernández-Barajas, Juan Francisco González-Guerrero, María Fernanda Noriega-Iriondo, Ilse Alejandra Ramírez-Sánchez, Laura Elia Martínez-de-Villarreal
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2019-07-01
Schriftenreihe:BMC Cancer
Schlagworte:
Pathogenic variant
BRCA1 and BRCA2 genes
Triple-negative subtype
Hereditary
Breast cancer
Online Zugang:http://link.springer.com/article/10.1186/s12885-019-5950-4

Online

http://link.springer.com/article/10.1186/s12885-019-5950-4

Ähnliche Einträge