Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier

Excessive neutrophil extravasation can drive immunopathology, exemplified in pyogenic meningitis caused by Streptococcus pneumoniae infection. Insufficient knowledge of the mechanisms that amplify neutrophil extravasation has limited innovation in therapeutic targeting of neutrophil mediated patholo...

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Bibliographic Details
Main Authors: Eliza Gil, Cristina Venturini, David Stirling, Carolin Turner, Liku B. Tezera, Giuseppe Ercoli, Tina Baker, Katharine Best, Jeremy S. Brown, Mahdad Noursadeghi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
meningitis
blood-brain barrier
neutrophils
pericytes
macrophages
Streptococcus pneumoniae
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.935798/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.935798/full

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