Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs) such as WASP, plays an important role in many actin-mediated cellular processes. In yeast, Arp2/3-mediated actin filament assembly drives endocytic membrane invagination and vesicle scission. Here we used ge...

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Bibliographic Details
Main Authors: Yidi Sun, Nicole T Leong, Tommy Jiang, Astou Tangara, Xavier Darzacq, David G Drubin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
WASP (yeast Las17)
WIP (yeast Vrp1)
Intersectin (Pan1-End3-Sla1)
clathrin-mediated endocytosis
multivalent PRM-SH3 domain interactions
phase seperation
Online Access:https://elifesciences.org/articles/29140

Internet

https://elifesciences.org/articles/29140

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