LMP-420, a Small Molecular Inhibitor of TNF-α, Prolongs Islet Allograft Survival by Induction of Suppressor of Cytokine Signaling-1: Synergistic Effect with Cyclosporin-A
Inflammatory insults following islet transplantation (ITx) hinders engraftment and long-term function of the transplanted (Tx) islets. Using a murine model of ITx, we determined the role of LMP-420, a novel TNF-α inhibitor, both individually and in combination with the immunosuppressant cyclosporine...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-06-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368911X637371 |