Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells

Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells

Macrophages secrete a variety of pro-inflammatory cytokines in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) but abnormal release of cytokines unfortunately promotes cytokine storms. Dimethyl fumarate (DMF), an FDA-approved drug for multi...

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Bibliographic Details
Main Authors: Rui Yang, Shibo Sun, Yining Guo, Yao Meng, Haowen Liu, Meiyun Shi, Shui Guan, Jianqiang Xu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
dimethyl fumarate
thioredoxin reductase (TXNRD)
immunometabolite
selenoprotein
anti-inflammation
redox regulation
Online Access:https://www.mdpi.com/1420-3049/28/1/107

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https://www.mdpi.com/1420-3049/28/1/107

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