Iron-Catalysed Aerobic Oxidative C–C Bond Cleavage of Ketones for the Synthesis of Primary Amides

Iron-Catalysed Aerobic Oxidative C–C Bond Cleavage of Ketones for the Synthesis of Primary Amides

Abstract An iron-catalysed aerobic oxidative C–C bond cleavage of ketones for the synthesis of primary amides has been developed using TEMPO and oxygen as an oxidant. This reaction tolerates a wide range of substrates, and primary amides are obtained in good to excellent yields. Substrates with long...

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Bibliographic Details
Main Authors: Haosheng Zhan, Zhiwei Hu, Weihua Tao, Min Ling, Wei Cao, Jing Lin, Zhenhua Liu, Yu Wang, Zhongxue Fang
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2019-01-01
Series:SynOpen
Subjects:
c–c bond cleavage
ketone
primary amide
amide
iron-catalysis
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611676

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611676

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