Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift
Bacteria undergo nutrient fluctuations during repeated feast and famine cycles and need to metabolically adapt to these changes. Using quantitative proteomics, Zhu & Dai show that the stringent response of (p)ppGpp is crucial for the timely adaption of bacterial growth to both amino acid and car...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36254-0 |
| _version_ | 1811175827064225792 |
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| author | Manlu Zhu Xiongfeng Dai |
| author_facet | Manlu Zhu Xiongfeng Dai |
| author_sort | Manlu Zhu |
| collection | DOAJ |
| description | Bacteria undergo nutrient fluctuations during repeated feast and famine cycles and need to metabolically adapt to these changes. Using quantitative proteomics, Zhu & Dai show that the stringent response of (p)ppGpp is crucial for the timely adaption of bacterial growth to both amino acid and carbon downshift. |
| first_indexed | 2024-04-10T19:42:14Z |
| format | Article |
| id | doaj.art-a115f5d5955542148e52ec88b5ea1a5e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T19:42:14Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a115f5d5955542148e52ec88b5ea1a5e2023-01-29T12:16:22ZengNature PortfolioNature Communications2041-17232023-01-0114111510.1038/s41467-023-36254-0Stringent response ensures the timely adaptation of bacterial growth to nutrient downshiftManlu Zhu0Xiongfeng Dai1Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal UniversityHubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal UniversityBacteria undergo nutrient fluctuations during repeated feast and famine cycles and need to metabolically adapt to these changes. Using quantitative proteomics, Zhu & Dai show that the stringent response of (p)ppGpp is crucial for the timely adaption of bacterial growth to both amino acid and carbon downshift.https://doi.org/10.1038/s41467-023-36254-0 |
| spellingShingle | Manlu Zhu Xiongfeng Dai Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift Nature Communications |
| title | Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| title_full | Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| title_fullStr | Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| title_full_unstemmed | Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| title_short | Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| title_sort | stringent response ensures the timely adaptation of bacterial growth to nutrient downshift |
| url | https://doi.org/10.1038/s41467-023-36254-0 |
| work_keys_str_mv | AT manluzhu stringentresponseensuresthetimelyadaptationofbacterialgrowthtonutrientdownshift AT xiongfengdai stringentresponseensuresthetimelyadaptationofbacterialgrowthtonutrientdownshift |