LDH-A—Modulation and the Variability of LDH Isoenzyme Profiles in Murine Gliomas: A Link with Metabolic and Growth Responses

LDH-A—Modulation and the Variability of LDH Isoenzyme Profiles in Murine Gliomas: A Link with Metabolic and Growth Responses

Three murine glioma cell lines (GL261, CT2A, and ALTS1C1) were modified to downregulate the expression of the murine <i>LDH-A</i> gene using shRNA, and compared to shRNA scrambled control (NC) cell lines. Differences in the expression of LDH-A and LDH-B mRNA, protein and enzymatic activi...

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Bibliographic Details
Main Authors: Masahiro Shindo, Masatomo Maeda, Ko Myat, Mayuresh M. Mane, Ivan J. Cohen, Kiranmayi Vemuri, Avi S. Albeg, Inna Serganova, Ronald Blasberg
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
glioblastoma
LDH-A shRNA knock-down
LDH isoenzymes
LDH-A and LDH-B immunohistochemistry
tumor growth
immune-competent and incompetent host animals
Online Access:https://www.mdpi.com/2072-6694/14/9/2303

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https://www.mdpi.com/2072-6694/14/9/2303

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