Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

Abstract Background Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy. As this might be caused by an increased capacity to repair CDDP-induce...

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Bibliographic Details
Main Authors: Zuzana Cierna, Vera Miskovska, Jan Roska, Dana Jurkovicova, Lucia Borszekova Pulzova, Zuzana Sestakova, Lenka Hurbanova, Katarina Machalekova, Michal Chovanec, Katarina Rejlekova, Daniela Svetlovska, Katarina Kalavska, Karol Kajo, Pavel Babal, Jozef Mardiak, Thomas A. Ward, Michal Mego, Miroslav Chovanec
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Germ cell tumours
DNA repair
Nucleotide excision repair
XPA
Prognostic marker
Online Access:https://doi.org/10.1186/s12885-019-6496-1

Internet

https://doi.org/10.1186/s12885-019-6496-1

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