Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure

Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure

Chronic exposure to glucocorticoids (GCs) can lead to psychiatric complications through epigenetic mechanisms such as DNA methylation (DNAm). We sought to determine whether epigenetic changes in a peripheral tissue can serve as a surrogate for those in a relatively inaccessible tissue such as the br...

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Bibliographic Details
Main Authors: Fayaz Seifuddin, Gary Wand, Olivia Cox, Mehdi Pirooznia, Laura Moody, Xiaoju Yang, Jonathan Tai, Gretha Boersma, Kellie Tamashiro, Peter Zandi, Richard Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:Epigenetics
Subjects:
biomarker
blood-brain correlation
cushing's disease
dna methylation
epigenetics
glucocorticoids
tissue heterogeneity
Online Access:http://dx.doi.org/10.1080/15592294.2017.1334025

Internet

http://dx.doi.org/10.1080/15592294.2017.1334025

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