Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

TERT promoter mutations are the most common noncoding alterations in cancers, although some remain to be characterised. Here, the authors identify TERT promoter duplications across seven cancer types that are functionally equivalent to well-known hotspot TERT mutations and are clonal in a multifocal...

Full description

Bibliographic Details
Main Authors: Carter J. Barger, Abigail K. Suwala, Katarzyna M. Soczek, Albert S. Wang, Min Y. Kim, Chibo Hong, Jennifer A. Doudna, Susan M. Chang, Joanna J. Phillips, David A. Solomon, Joseph F. Costello
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33099-x

Internet

https://doi.org/10.1038/s41467-022-33099-x

Similar Items