Hsp70 in Liquid Biopsies—A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer

Hsp70 in Liquid Biopsies—A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer

In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane Hsp70-positive tumor cells actively release Hsp70 in small extracellular...

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Bibliographic Details
Main Authors: Caroline Werner, Stefan Stangl, Lukas Salvermoser, Melissa Schwab, Maxim Shevtsov, Alexia Xanthopoulos, Fei Wang, Ali Bashiri Dezfouli, Dennis Thölke, Christian Ostheimer, Daniel Medenwald, Martin Windberg, Matthias Bache, Martin Schlapschy, Arne Skerra, Gabriele Multhoff
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
Hsp70
sandwich ELISA
liquid biopsy
tumor biomarker
small extracellular vesicles
prediction
Online Access:https://www.mdpi.com/2072-6694/13/15/3706

Internet

https://www.mdpi.com/2072-6694/13/15/3706

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